Expression alterations define unique molecular characteristics of spinal ependymomas
نویسندگان
چکیده
منابع مشابه
Expression alterations define unique molecular characteristics of spinal ependymomas
Ependymomas are glial tumors that originate in either intracranial or spinal regions. Although tumors from different regions are histologically similar, they are biologically distinct. We therefore sought to identify molecular characteristics of spinal ependymomas (SEPN) in order to better understand the disease biology of these tumors. Using gene expression profiles of 256 tumor samples, we id...
متن کاملMolecular alterations in ependymomas.
Ependymal tumours are uncommon neoplasms of the central nervous system. Basic molecular alterations underlying their development are not so well defined in contrast to the astrocytic tumours. We compiled literature data on the molecular changes in ependymomas to show clinical and pathological correlations and review the prognostic factors that may much better predict their clinical behaviour.
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Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the...
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BACKGROUND Spinal intramedullary ependymoma is a rare disease with a wide range of clinical presentation, generally requiring surgical treatment. OBJECTIVE Report our experience and present our surgical technique to achieve total resection and cure. METHOD We present 12 consecutive cases of intramedullary ependymomas operated between 2000 and 2008 by the senior author (HT). The functional s...
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PURPOSE Myxopapillary ependymoma (MPE) is a distinct histologic variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently, the only effective treatment for MPE is gross-total resection. We characterized the genomic and transcriptional landscape of spinal ep...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.3715